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MAOIs - Coadministration of monoamine oxidase inhibitors (MAOIs) with particular opioids is connected to unusual reports of critical adverse reactions. There appear to be two sorts of interaction, an excitatory in addition to a depressive a person.Flipping the direction on the R2 and R1 bonds ends in the R- and S- enantiomers of O-Desmethyltramadol